think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I was doing yoga and walking everyday and meditating. Low mosaics had a miscarriage rate of 11.0%, None of these were statistically significant from the other (, Euploid embryos had an 8.6% miscarriage rate, All of the mosaics had a 20.4% miscarriage rate, <50% mosaic segmental embryos had a 13.6% chance of miscarriage, >50% mosaic segmental embryos had a 20.3% chance of miscarriage, <50% two whole chromosome mosaics had a 11.9% chance of miscarriage, <50% complex (>2 whole chromosomes) mosaics had a 26.7% chance of miscarriage, >50% two whole chromosome mosaics had a 39.9% chance of miscarriage, >50% complex (>2 whole chromosomes) mosaics had a 44.3% chance of miscarriage. Go figure, right?! How did your pregnancy turn out? We had 30 eggs retrieval. Is there any reasoning behind this- is it due to poor egg quality, poor sperm quality, or both? The usefulness comes when someone who is starting IVF and considering PGS testing. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. Thats what i needed to hear. Disclaimer: Any studies presented here may be contradicted by other studies. Did testing and just found out it was a triploid embryo so it had 69 chromosomes. (2016)looked at over 18,000 Day 5 embryo biopsies (usingthe older SNP technology) and reported the chances of an embryo beingeuploid(based on age): So up until 37 theres about a 50% chance of each blastocyst being a euploid, this cuts in half to about 25% at 42. A recent meta-analysis by Simopoulou et al. (2017)found that Day 5 euploids had a higherongoing pregnancyrate vs Day 6 euploids (51.9% vs 32.7%). Also - wanted to add that I think my husband and I both did antibiotics still with our new clinic. My husbands sperm analysis was only very slightly abnormal. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). (2018)found a slight reduction inlive birth ratecompared to single biopsied embryos (50% vs 58%), but this was notstatistically significant. Good luck and wishing baby dust your way soon! However, I just recently gave birth, so dont give up there are still lots of reasons to be hopeful esp if you make pgs normal blasts. I also am interested in doing an endo scratch beforehand and adding Viagra if the shots and scratch aren't doing the job. Im surprised there are still doctors out there who do not bring up this protocol. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. After my negative, we did ERA and had a hysteroscopy to correct a small septum. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. Reminder: I have an integrated glossary in the text (terms are underlined with a dotted black line, and when you tap on it a window will pop up with the definition). I"ve not had a chance to actually talk with my RE yet, hopefully I will tomorrow after I go back for monitoring. Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. We PGS tested the whole batch of embryos at once at the end of all the retrievals. Note that once you confirm, this action cannot be undone. But I dont think we can compare those two sets of numbers to really tell if PGS is increasing our success rates per age group. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! frustration and tears were worth it. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. Saw a heartbeat at 6 and 8 weeks then nothing at week 10. I plan on asking my RE for a Recurrent loss panel to be done and autoimmune testing (NK cells etc)and a different protocol. 2014). Most assume theyll get the stats that are reported per transfer without knowing if theyll get eligible blasts or not. Because of my age and being diagnosed with diminished egg reserve we did "embryo batching" and I had 4 rounds of egg retrievals before moving onto any transfers. sd84. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. I know how devastating loss can be but theres always, always hope. thank you for sharing! I agree with the others that you should push for some sort of testing or SOMETHING to investigate before trying again (if you haven't already). think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I had a chemical last November with a PGS normal embryo and was successful with the second FET in July. Has anyone had this happen and did any further testing determine the cause? Wondering if anyones had a similar experience or has any advice. Note that this is per transfer data. . Learn more about, Learn About What to Expect's Pregnancy & Baby App. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Will be put on lovenox this round as well. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. However, these differences were not found in women older than 30 years. Please can you offer a perspective? Im so confused as my RE says that morphology doesnt matter if theyre euploid. 2 - IVF BFN Some background on us: diagnosed with severe male factor IF 4 years ago, did one round of IVF/ICSI which resulted it a chemical pregnancy. A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus. Hi, i didnt have chemicals, I had bfn for my first two transfers. Thankful for these forums! I am curious to hear other peoples experiences, especially with 6 days blasts. Chemical pregnancy facts. Im assuming you had no issues shipping yours? I am so so sorry. Or they did but they were all aneuploid? Last January we found out we were pregnant but had a miscarriage at 7 weeks. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. Im absolutely going to ask for biopsy and check for endometritis. The majority of these studies used double embryo transfers, either when transferring euploid embryos, in the control untested groups, or both. My first fresh transfer ended in miscarriage due to low progesterone, I was on supplements but not enough. Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. Fast Facts About PGS Testing Risks. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. I just wish we had more answers so we can prepare for the next . I was more relaxed overall at the second transfer, and maybe that helped. Kelly. I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). Group Black's collective includes Essence, The Shade Room and Naturally Curly. I was wondering what protocol were you on for your second transfer? Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). I hope the ERA works too. Has anyone had a similar experience but had a viable pregnancy. Our RE recommends trying again, but it feels like insanity to try the same thing without changing/adding anything or doing some tests. Yeah now Im just rethinking everything. For the autoimmune stuff above I was tested by Alexander Kofinas. We decided to start with IUI with clomid which resulted in another chemical pregnancy. I actually didnt have embryos to bring with me when we switched. The embryo biopsy can be utilized to perform preimplantation genetic screening or PGS. thanks so much! I also went for a lot of second opinionsall of the drs said there were many reasons and theories for why pgs embryos fail but its not uncommon. I think its valuable information because many people dont realize the chances of not getting blasts/eligible blasts for biopsy. We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. Check mycomplete guide to mosaic embryosto learn more about mosaics, or mycomplete guide to PGT-Ato get more background on PGT-A (akaPGStesting). Please whitelist our site to get all the best deals and offers from our partners. But then the 3 mature eggs I had all fertilized, all made it to blast, all tested normal, and now one of them is my 15 month old daughter. I got my period or should I say we officially begun to miscarry on Saturday so I did call them with our Day 1. This is important because miscarriage rates with advancing female age. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. I'm curious if this might have something to do with it. - continued the same above protocol with the only change was that once I got my first positive beta (63) they had me increase the progesterone suppository to three times a day. Did you carry to full term? It is seriously invaluable to me. You can check out my summary of the study here.. Of the 414 blastocysts transferred: 312 were euploid, 73.1% had a clinical pregnancy and 7.2% miscarried; 102 were aneuploid, 23.5% had a clinical pregnancy and . Now I wonder if that could have been the culprit. Best of luck to you. At least testing a few variables like blood clotting. Congratulations on your pregnancy xxx I have a whole page dedicated to mosaic embryos. (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. Thanks for sharing! The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Miscarriage of PGT tested embryo. Miscarriage is defined as a loss between clinical pregnancy (detection of a gestational sac or heartbeat) and 20 weeks of gestation. My TSH was marginally high and I started synthroid. I have considered going to Braverman in NYC but I think that Kofinas tested me for everything Braverman tests for. Hi everyone. My clinic does allow each patient to continue with one retrieval with only 1-2 follicles, however, for cost reasons since we're doing ICSI and PGS testing I'm considering cancelling the cycle.
