Leong, H., Firestone, G. L., and Bjeldanes, L. F. Cytostatic effects of 3,3'-diindolylmethane in human endometrial cancer cells result from an estrogen receptor-mediated increase in transforming growth factor-alpha expression. 7-20-2007;282(29):21542-21550. View abstract. View abstract. The outcomes may be good or bad, depending on the amount of hormones and DIM in your body, reports a study in the July 2014 issue of "BMC Cancer.". April 15, 2023, by Jeffrey Morrison Thyroid. It's not for me. In other words, DIM helps our bodies get rid of what it doesn't need and create what it does. The good news is that following an estrogen detox diet can help balance out your hormone levels and reverse estrogen dominance naturally and safely. View abstract. Should I take DIM if I have low estrogen? Li, Y., Li, X., and Guo, B. Chemopreventive agent 3,3'-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases. Whats a Headache Diary and How Can It Help? Vivar, O. I., Lin, C. L., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status. Select a condition to view a list of vitamins. The third week is often much improved from a physical standpoint, with almost all physical symptoms as well as insomnia frequently being resolved or very close to it. DIM has been recommended for women who show symptoms of estrogen dominance which include, but are not limited to: heavy periods, periods lasting longer than 7 days, menstrual cycles shorter than 25 days, and PMS symptoms such as major mood swings, irritability, uncontrollable anger, and feelings of depression. Limit consumption of refined sugar, table salt and saturated fats as these increase stress on the liver. Carcinogenesis 2006;27(4):717-728. We provide the nutrients you need to power your active lifestyle. J.Cell Biochem. Diindolylmethane might act like estrogen in the body, but might also block estrogen effects. Drinking plenty of water and getting enough fiber through whole foods can help the body push toxins out of the body. We believe thateveryone can optimize not only their athleticperformancebut their human potential. These glutamate interactions, among other somewhat mysterious mechanisms, is one of the ways it acts as a cough suppressant. 6-1-2009;107(3):516-527. kids, work deadlines, traffic, etc.) B. and Ichikawa, H. Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Female sex hormones help conduct our sleep cycle and overall mood; How Baseline+ May Help, Why you should consider switching your energy supplements. Because of this, we cannot say how long it would take to work, but we know that using DIM under a doctors supervision can do more good than harm for most women. Instead, it boosts your bodys capacity to metabolize estrogen, so your lifestyle choices (diet, exercise, etc.) . 2023 DailyBenefit.com Take DIM with Milk Thistle for Liver detox & Endometriosis: Taking DIM with another supplement called milk thistle has been shown to reduce the severity of endometriosis. Notify me when this product is available: DIM Detox promotes healthy cell cycle function and hormone metabolism to support the liver's natural detoxification process. This field is for validation purposes and should be left unchanged. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Dong, L., Xia, S., Gao, F., Zhang, D., Chen, J., and Zhang, J. J.Nutr. If the lowest dose isnt effective after a month or so, your doctor will increase the dose over time until your symptoms are significantly relieved. View abstract. Read on to find out how to balance your hormones and forget about hormonal imbalance symptoms! The acids in your stomach turn indole-3-carbinol, a phytochemical in cruciferous vegetables such as broccoli and cabbage, into DIM. But something that helps take away the side effects of DIM is Calcium-D-Glucarate. Garikapaty, V. P., Ashok, B. T., Tadi, K., Mittelman, A., and Tiwari, R. K. Synthetic dimer of indole-3-carbinol: second generation diet derived anti-cancer agent in hormone sensitive prostate cancer. 2003;41(6):745-752. One of the most significant things DIM may do for women is improve estrogen metabolism. Disturbing how a company that charges $600 every 3 months for pelleting, insists. The study in "BMC Cancer" reported that different concentrations of DIM may lead to different biological outcomes. Diindolylmethane might change how quickly the liver breaks down these medications. As with any detox, the symptoms are not long lasting and the rewards far outweigh any short-term discomfort you may experience. 2002;132(11):3314-3324. DIM is a phytoestrogen and not an anti-estrogen DIM blocks mTOR and subsequently inhibits growth Very low doses of DIM as found as a component of foods with the necessary cofactors works in the gut and liver to manipulate estrogen detox and support healthy estrogen metabolite ratios to prevent estrogen dominance Biochem Pharmacol 2000;60:167-77. Bcl-2 family-mediated apoptotic effects of 3,3'-diindolylmethane (DIM) in human breast cancer cells. Denver, CO 80222. Overall, there is no such thing as a DIM detox and you likely will not experience any DIM detox symptoms. Breast Cancer Res.Treat. Dehydration can cause headaches. These are the symptoms of dextromethorphan withdrawal, and depending on someones use habits, they may range from a little uncomfortable, to potentially life-threatening. Kim, E. J., Shin, M., Park, H., Hong, J. E., Shin, H. K., Kim, J., Kwon, D. Y., and Park, J. H. Oral administration of 3,3'-diindolylmethane inhibits lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice. DIM may interact with medications, so avoid supplements if you take prescription medications. 6 (Nov., 2000), pp. 5-15-2006;132(2):208-213. Then stay connected with our team for important wellness info and be the first to know about the latest Denver Vein news, including: Drop your email below to get on our list! While no federal regulations exist currently, there are state-level bills and laws being passed to prohibit or otherwise regulate the sale of dextromethorphan to people under the age of 18, but these vary by state. We avoid using tertiary references. Biochem.Pharmacol. View abstract. Chen, D. Z., Qi, M., Auborn, K. J., and Carter, T. H. Indole-3-carbinol and diindolylmethane induce apoptosis of human cervical cancer cells and in murine HPV16-transgenic preneoplastic cervical epithelium. Kale. Biochem.Pharmacol. According to studies, those who are exposed to heightened levels of stress from normal everyday stressors (I.e. Find out about home remedies to ease. DIM works to modulate the expression and activity of certain enzymes. how long should you take DIM supplements? DIM Detox includes ingredients to support healthy detoxification, estrogen metabolism, and cell cycle activity: *These statements have not been evaluated by the FDA and are not intended to treat or cure any disease. Br J Cancer. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. 2008;17(10):2619-2624. DIM binds to androgen receptors, inhibiting changes in the skin, such as increased oil production and clogged pores. We believe thateveryone can optimize not only their athletic, but their human potential. Ann N Y Acad Sci 1999;889:204-13. Unaddressed, Czerwony says the long-term consequences can include elevated risks of: Type 2 diabetes. Anticancer Drugs 1998;9(2):141-148. Swolverineis an athleteand active lifestyle brand. Kim, E. J., Park, S. Y., Shin, H. K., Kwon, D. Y., Surh, Y. J., and Park, J. H. Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells. Increased estrogen canalsobe caused by poor sleep habits, which inhibit the production of melatonin, a hormone that can also protect against estrogen dominance[R]. Taking DIM can help with menopause symptoms like weight gain, hot flashes, mood swings, etc. The results showed that after supplementing with 150mg of DIM for 6 months, 70 percent experienced at least one non-serious side effects. These symptoms can include, headaches, irritability, body aches, flulike symptoms, changes in bowel movements (most commonly diarrhea), fatigue and insomnia. Toxicol.Sci. 3-11-2008;88(10):661-664. Since DIM affects how a womans body produces estrogen metabolites, it can be an effective addition to a hormone replacement treatment plan. 5-1-2006;66(9):4880-4887. View abstract. View abstract. It appears to help destroy cancer cells and reduce swelling. It has its own timing when it comes to absorbing supplements. 2015 Aug;42(4):401-8. This Nrf2/ARE process serves a protective role in the body. 2010;116(3):464-467. You will need to take DIM daily for at least 30 days before deciding if it works for you. DIM also increases the uptake of naturally occurring testosterone in your body therefore stimulating muscle growth and optimizing fat loss. View abstract. View abstract. There are several other stimulant drugs that can produce uncomfortable or even dangerous withdrawal symptoms. Diindolylmethane has been shown to help reduce the effects of poor sleep through the regulation of estrogen levels. Biochem.Pharmacol. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study. DIM Detox promotes healthy cell cycle function and hormone metabolism to support the liver's natural detoxification process. facebookads, Natl Inst Health, Natl Inst Environmental Health Sci. Bad estrogen can pack on the pounds, especially around your hips and buttocks. I experienced terrible headaches, indigestion, nausea, vomiting. Progesterone in particular plays a crucial role in sleep quality, Protea Nutrition was built upon the foundation of creating naturally based supplements that help improve the customers health on a cellular level. Side effects of DIM include, but are not limited to. 3,3'-Diindolylmethane and genistein decrease the adverse effects of estrogen in LNCaP and PC-3 prostate cancer cells. Commonly, they start with fasting no food or drink. ~HB Support. One type of detox, a detoxification diet, is designed to eliminate toxins from your body. Both medication and clinical therapy can be very effective at reducing the risks and the severity of these symptoms. 2009;139(12):2373-2379. Female sex hormones including estrogen and progesterone help conduct our sleep cycle and overall mood. View abstract. Please leave your valid email address below. Yet, DIM has so many other notable benefits beyond hormonal health that can improve overall health and wellness. Allergies arent the only problem caused by overactive mast cells. All rights reserved. However, we need additional research on how DIM could effectively prevent breast cancer or be an adjuvant therapy for women who already have breast cancer. Mol Cancer Ther. Diindolylmethane (DIM) has been the topic ofrecent discussions surroundinghormonal health. Pancreatitis. Gamet-Payrastre, L., Lumeau, S., Gasc, N., Cassar, G., Rollin, P., and Tulliez, J. J Steroid Biochem Mol Biol. Check the article to learn more about the mast cell. Taurine, glycine and methionine promote phase II detoxification pathways and healthy cell metabolism., Dr. Ohhira's Essential Formula Probiotics. PLoS One 2013;8(9):e74916. To get enough DIM through food, one would have to eat at least 2 lbs. DIM supports the expression of antioxidant and phase II detoxifying enzymes, which protect tissues from oxidative stress, toxins and reactive substances. 21,3 (2011): 299-304. We cover what to expect with lumbar puncture (spinal) headaches, including how long they last and how to treat them. Anticancer Res. Parkin, D. R. and Malejka-Giganti, D. Differences in the hepatic P450-dependent metabolism of estrogen and tamoxifen in response to treatment of rats with 3,3'-diindolylmethane and its parent compound indole-3-carbinol. Some of the post-acute symptoms of dextromethorphan withdrawal include: These symptoms have been known to persist for weeks, months, or rarely even years after the last time someone used dextromethorphan. Stroke. The incidence of thyroid cancer is 4-5x higher in women than men, suggesting that estrogen plays a significant role in thyroid disease. View abstract. View abstract. View abstract. 2006;15(12):2477-2481. If you are seeking drug and alcohol related addiction rehab for yourself or a loved one, the sponsored hotline is a confidential and convenient solution. Cancer Epidemiol.Biomarkers Prev. This could change the effects and side effects of these medications. For some women, it may take six months to see optimal results. It may also have an anti-testosterone impact. The important role Iron plays in breastfeeding & pregnant women, Benefits of L-citrulline malate in Vitality+. We provide the nutrients you need to power your active lifestyle. This requires effective psychiatric and therapeutic care if dangerous outcomes are to be avoided. Glucosinolates in broccoli, including indole-3-carbinol and sulforaphane, help support healthy detoxification. Once it's absorbed into your system, DIM is an active ingredient that influences the activity of estrogen and, in some instances, regulates the activity of genes. Dextromethorphan, also known as DXM, is a common ingredient in cough medications such as Robitussin, and until recently, there were no regulations regarding the sale of dextromethorphan in America. Four . It is used to help support the metabolism and elimination of dangerous forms of estrogens which enter the body through xenoestrogens and cause hormonal imbalances. Not Taking DIM is not an option. We list many common conditions you might want to take a DIM supplement for, and tell you how long it may take to work for each, and how clear the guidance is as yet on its effectiveness for those conditions. In this article, we will look at how dextromethorphan works, the symptoms of withdrawal, the timeline involved, the physiological effects of dextromethorphan withdrawal, and some scenarios when a dextromethorphan detox center may be especially recommended. View abstract. Chang, Y. C., Riby, J., Chang, G. H., Peng, B. C., Firestone, G., and Bjeldanes, L. F. Cytostatic and antiestrogenic effects of 2-(indol-3-ylmethyl)-3,3'-diindolylmethane, a major in vivo product of dietary indole-3-carbinol. This may result in: Along with headaches, other symptoms during a detox diet may include: When reading about these detoxes, the symptoms may be called various names including healing reactions, cleansing reactions, detox symptoms, and healing crises. Supports antioxidant defence and detoxification. Thus promoting good estrogen vs. bad estrogen ratios[R]. About one-fourth of the women experienced an increase in bowel frequency, while 18 percent had headaches or gas. Kim, Y. H., Kwon, H. S., Kim, D. H., Shin, E. K., Kang, Y. H., Park, J. H., Shin, H. K., and Kim, J. K. 3,3'-diindolylmethane attenuates colonic inflammation and tumorigenesis in mice. Rogan, E. G. The natural chemopreventive compound indole-3-carbinol: state of the science. maximizes your bodys ability to stimulate muscle growth by promoting high-quality sleep and naturally boosting testosterone levels. View abstract. DIM may lead to positive -- or negative -- effects on various types of hormone-sensitive cancers. 2001;61(1):40-48. When indole-3-carbinol mixes with your stomach acid, it creates a chemical reaction that converts it to Diindolylmethane (DIM). 2016;2016:7527098. View abstract. Pre-menopausal and post-menopausal symptoms are caused by fluctuations and the eventual decrease of estrogens in a woman's aging body. The symptoms of dextromethorphan withdrawal can also vary in both intensity and duration, sometimes substantially, between different people. This may result in: a reduction in circulating hormones . 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot studyThyroid : official journal of the American Thyroid Associationvol. Headaches can disrupt a child or teen's school day. View abstract. All Products, Cauliflower. Not only does DIM effect hormonal health, but it also naturally speeds up your metabolism, eliminates hormonal acne, stimulates muscle growth, and promotes thyroid health, with minimal non-serious side effects. Detox headaches are often caused by your bodys reaction to missing an item, such as sugar or caffeine, that was habitually present. 2020;41(10):1395-1401. "Water pills" can also decrease sodium levels. Good estrogen has the ability to protect the heart and brain with antioxidant activity, promote cell growth, and rid the body of damaged cells. View abstract. J.Nutr. Androgens are considered male sex hormones because they give men their masculine features. Nearly 13 percent of the women reported changes in their menstrual cycle when they took DIM. Oncogene 3-31-2005;24(14):2343-2353. Carter, T. H., Liu, K., Ralph, W., Jr., Chen, D., Qi, M., Fan, S., Yuan, F., Rosen, E. M., and Auborn, K. J. Diindolylmethane alters gene expression in human keratinocytes in vitro. A pilot study investigated the antiestrogen effects of DIM by supplementing patients with 300m of DIM per day. When patients present with elevated laboratory levels of estrogen and/or have symptoms related to excess estrogen, strategies often include supplements such as diindolylmethane (DIM) or indole-3-carbinol (I3C). Cancer Epidemiol.Biomarkers Prev. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. The most common was darkening of the urine. Carcinogenesis 2002;23(8):1297-1305. View abstract. Hong, C., Kim, H. A., Firestone, G. L., and Bjeldanes, L. F. 3,3'-Diindolylmethane (DIM) induces a G(1) cell cycle arrest in human breast cancer cells that is accompanied by Sp1-mediated activation of p21(WAF1/CIP1) expression. Some people may see noticeable results in four days, and for others, it may take 30 days or more. View abstract. View abstract. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Made for the elite athlete and the strong-willed our products were designed to fuel your athletic performance. . Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Dextromethorphan, even though it is derived from morphine, does not have appreciable interactions with opioid receptors. Bad estrogen associated with obesity has been implicated as one of the primary risk factors in the development of cancer-causing tumors in breast tissue[R], In addition to keeping good estrogen in the body, DIM also works to inhibit aromatase, the enzyme that converts testosterone into estrogen. For example, DIM has an anti-estrogenic effect, which may reduce the risk of developing thyroid cancer, according to a study in "Thyroid" in March 2011. Yasuda, Michiko T et al. DIM Supplement: How Long Does it Take to Work? Leong, H., Riby, J. E., Firestone, G. L., and Bjeldanes, L. F. Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways. Learn tips to help relief pain like drinking more water and using relaxation techniques. When youre participating in a detox, its common to experience headaches. View abstract. Carcinogenesis 1998 Sep;19:1631-9. Is Mast Cell Activation Behind Your Chronic Symptoms? The data suggested that DIM enhanced estrogen metabolism and could potentially reduce the risk of developing thyroid cancer by decreasing estrogen levels[R]. If you choose to stop taking DIM supplements, you do not need to wean yourself off of it. View abstract. Our website services, content, and products are for informational purposes only. 2011 Mar;21(3):299-304. Estrogen requires a metabolic pathway similar to that of DIM thus promoting good estrogen production. DIM has the potential to alter your menstruation since it changes your estrogen levels. We have more in-depth withdrawal guides for drugs such as: Disclaimer: The information provided on DetoxLocal.com is intended for educational purposes and is not a substitute for professional medical treatment. Nutr Cancer 2004;50(2):161-167. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. Hsu, E. L., Chen, N., Westbrook, A., Wang, F., Zhang, R., Taylor, R. T., and Hankinson, O. CXCR4 and CXCL12 down-regulation: a novel mechanism for the chemoprotection of 3,3'-diindolylmethane for breast and ovarian cancers. Therapeutic Research Faculty 2020. Since DIM acts on sex hormones, you may be asking yourself is DIM supplement good for PCOS? The answer isnt yet clear. After its over you usually feel better like Any detox. Vomiting and Stomach Cramps Diarrhea Increased Irritability Tachycardia (increased heart rate) Hypertension (elevated blood pressure) Myoclonus (muscle spasms) With the physical symptoms reducing during the second week and stomach issues resolving, being able to eat and sleep more may help improve the subjective experience of other symptoms. Your body is unique. The exact way this works is unclear, although it most likely has to do with the combination of NMDA antagonism, -1 receptor stimulation, and serotonin reuptake inhibition, somewhat similar to more classic hallucinogens. It is hypothesized that these symptoms resemble the body going through a period of detox since; bad estrogen is being pulled out of your cells and essentially eliminated out of the body. It just doesn't need added sugars. Hi, some find that when they start DIM, certain symptoms get worse. There was some speculation about the efficacy of DIM as an estrogen blocker so I'm a little worried about taking more.. 1. of cabbage, Brussels sprouts, or kale a daywhich is pretty . Ge, X., Fares, F. A., and Yannai, S. Induction of apoptosis in MCF-7 cells by indole-3-carbinol is independent of p53 and bax. 2003;133(4):1011-1019. Taking "water pills" along with diindolylmethane might make sodium levels drop too low. View abstract. Some herbs suggested for natural headache relief include: Advocates of natural healing feel that meditation will help with detox headaches by relaxing your central nervous system, increasing oxygen supply to your brain, and reducing stress. Degner, S. C., Papoutsis, A. J., Selmin, O., and Romagnolo, D. F. Targeting of aryl hydrocarbon receptor-mediated activation of cyclooxygenase-2 expression by the indole-3-carbinol metabolite 3,3'-diindolylmethane in breast cancer cells. View abstract. Last medically reviewed on July 17, 2018. The most common side effect was darkening of the urine. Gynecol.Oncol. J Pharmacokinet Pharmacodyn. So when you take DIM for hormonal acne, you can expect your skin to start clearing up anywhere from 3 days to 30 days depending on your unique situation. These are strictly psychological in nature, but they can still be present significant challenges to someones continued sobriety and health. Sometimes it may block the effect of estrogen, while it may enhance estrogen activity in other circumstances. OR submit you number and someone will call you shortly! Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Zhao, Y. Y., Zhou, L., Pan, Y. In Vivo 2006;20(2):221-228. You can learn more about how we ensure our content is accurate and current by reading our. If youve got hormonal acne, youre probably in a hurry to get rid of it. View abstract. 1993;46(6):791-798. Until more is known about the safety of diindolylmethane, children and pregnant or nursing women should not take DIM supplements. 3-1-2010;79(5):715-721. Mol.Pharmacol. Rahman, K. W., Li, Y., Wang, Z., Sarkar, S. H., and Sarkar, F. H. Gene expression profiling revealed survivin as a target of 3,3'-diindolylmethane-induced cell growth inhibition and apoptosis in breast cancer cells. Biochem.Biophys.Res.Commun. Some users have complained of hormone-related problems resulting from supplementation. View abstract. Turnips. Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A. Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. That being said, we can look to a few case studies to illustrate a rough, generalized timeline. 2010;49(7):672-683. Z., Zhao, L. J., Liu, Y. N., Yu, H., Li, Y., and Zhao, X. J. Accepted file types: pdf, doc, docx, odt, rtf, Max. Nachshon-Kedmi, M., Yannai, S., Haj, A., and Fares, F. A. Indole-3-carbinol and 3,3'-diindolylmethane induce apoptosis in human prostate cancer cells. Why? Support the liver's natural detoxification process and cellular health*, Made from broccoli and other naturally-sourced ingredients. View abstract. However, depending on the severity of the imbalance, detoxification can cause the individual to feel worse, before they feel better. With an abundance of information about supplementation out there, its difficult to knowexactlywhat is best for your body without feeling like youre exposing it to unnecessary and harmful chemicals. Other Supplements, Carcinogenesis 2005;26(4):771-778. DIM converts estrogen and reduces its effect. Yerushalmi R, Bargil S, Bar Y, et al. View abstract. J.Nutr. This information may not fit your specific health circumstances. Calls to any sponsored hotline (non-facility) will be answered by: If you wish to contact a specific medical detox center then find a specific detox center using our detox locator tool. Some people may even stop the use of these helpful natural substances before their body has a chance to fully rid itself of the toxins due to these detox symptoms. View abstract. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5 alpha-reductase inhibitor. RELATED ARTICLE How To Effectively Reduce Your Stress. Flax seeds - Flax seeds are a promoter of CYP1A1 and an inhibitor of CYP1B1. While some of these reactions are inevitable and can, in fact, signify that these toxins are making their exit, there are some other actions one can take to support the lymphatic system, liver, kidneys and gut. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2006;98(2-3):133-8. View abstract. If you stop using opiates after becoming dependent, you can experience uncomfortable symptoms of withdrawal. These include: Weight gain Bloating Acne Headaches Worsened PMS symptoms Emotional disturbances ( depression, anxiety, mood swings) 1978;38(5):1410-1413. The post-acute withdrawal symptoms are the longer-lasting, but less intense, symptoms that commonly linger for weeks or months after the acute withdrawal phase has ended. Luckily, there are natural ways to improve Nrf2 and strengthen our detox pathways. While these events may have some benefits, they wildly oversimplify the concept of detoxification. So, the benefits of taking DIM are so many, that every woman can benefit from it. J.Nutr. View abstract. More and more research shows that DIM can play a protective role against breast cancer. View abstract. Inflammation slows this transport process down and can make phase 3 estrogen detox slow leading to unwanted excess estrogen symptoms (mood swings, breast tenderness, painful, heavy periods, etc.)

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