Sci. Sci. 374, 381388 (2000). IDOL G51S variant is associated with high blood cholesterol and increases low-density lipoprotein receptor degradation. The sterol transporting heterodimer ABCG5/ABCG8 requires bile salts to mediate cholesterol efflux. A Mechanism for Electrophilic Substitution Reactions of Benzene A two-step mechanism has been proposed for these electrophilic substitution reactions. CAS Cancer Res. Das, A., Davis, M. A. A product generated from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) by the action of HMG-CoA reductase. 13, 376388 (2011). 54, 21742184 (2013). Vasc. 274, 1106011071 (1999). Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Gustafsen, C. et al. Sci. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. Ren, R. B. et al. Article PubMed A surveillance system that clears misfolded proteins in the endoplasmic reticulum (ER) via ubiquitylation and proteasomal degradation. Nature 343, 425430 (1990). Nat. J. Biol. Oncogene 35, 63786388 (2016). Sci. Res. J. Med. An adaptor protein that binds low-density lipoprotein receptor and mediates its endocytosis in hepatocytes and lymphocytes. Pandzic, E. et al. Rodgers, J. T. & Puigserver, P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Human acyl-coenzyme A:cholesterol acyltransferase expressed in Chinese hamster ovary cells: membrane topology and active site location. VLDLs enable fats and cholesterol to move within the water-based bloodstream. China Life Sci. Freeman, L. A. et al. Cellular localization and trafficking of the human ABCG1 transporter. Kim, Y. C. et al. 1, 379391 (2005). USA 110, 50345039 (2013). Biol. Eid, W. et al. Li, Y. et al. J. Cell. Nature Reviews Molecular Cell Biology Nat. Tarling, E. J. Sci. Xu, D. Q. et al. eLife 8, e44396 (2019). Tan, J. M. E. et al. Widenmaier, S. B. et al. Mol. Cell. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. The ATP binding cassette transporter, ABCG1, localizes to cortical actin filaments. J. Physiol. Circulation 111, 23732381 (2005). Chem. Schmitz, G. & Grandl, M. The molecular mechanisms of HDL and associated vesicular trafficking mechanisms to mediate cellular lipid homeostasis. Biophys. Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase. Nat Rev Mol Cell Biol 21, 225245 (2020). Yu, L. Q. et al. Lagace, T. A. PCSK9 and LDLR degradation: regulatory mechanisms in circulation and in cells. Horton, J. D., Bashmakov, Y., Shimomura, I. Lee, J. Y. et al. This work shows that lipid overloading increases ROS that oxidizes ACAT2 on Cys277, thereby decreasing ubiquitylation of the protein. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Acta Mol. 50, S172S177 (2009). Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol. Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3. 122, 12621270 (2012). Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Cell. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. Proc. A central regulator ofenergy homeostasis that is activated when the cellular ATP level is low. Chem. Mol. 280, 3015030157 (2005). J. Clin. Cancer Res. This work determines that in Chinese hamster ovary cells the ER cholesterol, exceeding 5% of total membrane lipids, will block SREBP activation. J. Biol. Requirement of myosin Vb.Rab11a.Rab11FIP2 complex in cholesterol-regulated translocation of NPC1L1 to the cell surface. Ayden Harrison. Chem. Nguyen, T. M., Sawyer, J. K., Kelley, K. L., Davis, M. A. What is the role of acetic acid in the bromination of cholesterol reaction? Experiment 5 - Bromination of Cholesterol. J. Physiol. revised it. J. Biol. 13, 260273 (2011). Science 349, 187191 (2015). Zhang, L. et al. J. Biol. Biochim. 59, 749763 (2018). Sci. 60, 17651775 (2019). Song, B. L. et al. The second part of the mechanism involves reaction of the benzene p-bond with either the Lewis acid-base adduct (shown) or simply with Br to provide a carbocation intermediate. Res. Horton, J. D., Cohen, J. C. & Hobbs, H. H. PCSK9: a convertase that coordinates LDL catabolism. These protein complexes comprise multiple cytosolic subunits. Endocrinol. Science 290, 177117751 (2000). Nat. Chem. Bao-Liang Song. Google Scholar. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme. ACAT1 and ACAT2 membrane topology segregates a serine residue essential for activity to opposite sides of the endoplasmic reticulum membrane. Rev. & Porter, T. D. Cloning, heterologous expression, and enzymological characterization of human squalene monooxygenase. A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis. Am. Chua, N. K., Hart-Smith, G. & Brown, A. J. Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase. Chem. & Dong, X. C. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. Biol. Nat. 276, 3943839447 (2001). Experiments have shown that when the alkane and halogen reactants are not exposed . Cholesterol binds to the N-terminal domain of NPC1L1 and induces the dissociation of YVNxxF from the plasma membrane, allowing it to be recognized and bound by NUMB. J. Biol. Proc. J. Biol. Chem. You are using a browser version with limited support for CSS. Chu, B. J. A subgroup of steroids with ahydroxyl group at the C-3 position of the A-ring. Cholesterol-regulated translocation of NPC1L1 to the cell surface facilitates free cholesterol uptake. & Dong, X. C. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. Arterioscler. Moon, S. H. et al. Commun. Cell Metab. Chem. Res. China Life Sci. Li, J. Drug Discov. Cell 73, 458473 (2019). Gastroinest. Nuclear factor-B regulates the expression of multiple genes encoding liver transport proteins. Bartuzi, P. et al. Vasc. Willner, E. L. et al. Istvan, E. S., Palnitkar, M., Buchanan, S. K. & Deisenhofer, J. A. Nucleophile B. Solvent C. byproduct D. electrophile 3. CHEM 223. Provided by the Springer Nature SharedIt content-sharing initiative, Journal of Animal Science and Biotechnology (2023), Nature Reviews Molecular Cell Biology (Nat Rev Mol Cell Biol) 278, 4827548282 (2003). Jo, Y. et al. Chu, B. A process of faecal excretion ofplasma-derived cholesterol from the inside of enterocytes to the intestinal lumen. Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. Bromination is a chemical reaction involving the reaction of a compound, and bromine results in bromine being added to the compound. Zhang, Y. et al. The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and the cholesterol synthesis pathway. Purpose This reaction involves nucleophilic attack by the alkene on bromine, forming a tertiary carbocation with bromonium ion character. Structure of the LDL receptor extracellular domain at endosomal pH. Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression. Acta 380, 357369 (1975). Mol. The emphasis has been changed from the purification of cholesterol to a structure determination, conformation, stereochemistry, and mechanism investigation. & Tamehiro, N. ABC transporters, atherosclerosis and inflammation. Cell. Goossens, P. et al. The complex that catalyses theubiquitylation of proteins for degradation. & Dietschy, J. M. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation. Some sirtuins can remove various acyl lysine modifications from proteins. Liu, T. F. et al. 24, 783794 (2016). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Gelissen, I. C. et al. Correspondence to Biophys. The interface formed between an antigen-presenting cell or target cell and a lymphocyte such as a T cell, B cell or natural killer cell. Cao, J. et al. Arterioscler. Circ. Circulation 110, 20172023 (2004). Sci. Res. Rev. Cooperative interaction between hepatocyte nuclear factor 4 and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Each ganglioside molecule is composed of a glycosphingolipid linked to oneor more sialic acid. 85, 13431372 (2005). Song, B. L., Javitt, N. B. Natl Acad. Science 274, 255259 (1996). J. Biol. Sci. J. Biol. USA 101, 97749779 (2004). Yang, T. et al. J. Biol. NRF1 is an ER membrane sensor that is central to cholesterol homeostasis. J. Lipid Res. Cell Biol. Hwang, S. et al. Chem. 10, 97 (2019). Jeon, H. & Blacklow, S. C. Structure and physiologic function of the low-density lipoprotein receptor. Puerarin promotes ABCA1-mediated cholesterol efflux and decreases cellular lipid accumulation in THP-1 macrophages. 289, 2402024029 (2014). Thin tubes formed by intercellular space between hepatocytes. Figure: Step 1 in mechanism of addition of Bromine to ethene The bromonium ion is then attacked from the back by a bromide ion formed in a nearby reaction. 53, 19321943 (2012). 279, 2291322925 (2004). Sci. J. Biol. Davis, H. R. et al. DISCUSSION. Biochem. Sci. 40 Report Document Comments Please sign inor registerto post comments. Curr. J. Biol. Bromination was the method chosen to remove traces of 3B-cholestanol, 7-cholesten-3b-ol, and 5,7-cholestadien-3B-ol that were assumed to be present in the sample used. 39, 24682479 (2019). Costet, P., Luo, Y., Wang, N. & Tall, A. R. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. USA 100, 1202712032 (2003). Morris, L. L., Hartman, I. Zhang, J. H. et al. d-Glucose modulates intestinal NiemannPick C1-like 1 (NPC1L1) gene expression via transcriptional regulation. Clarke, P. R. & Hardie, D. G. Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver. 49, 17701781 (2008). ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Debromination of 473 and 468 was achieved by heating with sodium sulfite in aqueous solution to give 456 (1987ACSA(B)724).The 4,5-dibromo compound 476 was debrominated regioselectively furnishing the 4-bromo compound 473 (1987ACSA(B)724).The regioselectivity reflects that the 5-anion 475 according to H/D exchange rates is formed faster than the 4-anion 474 (Scheme 138). Kotzka, J. et al. Nat. Sci. Wang, N., Ranalletta, M., Matsuura, F., Peng, F. & Tall, A. R. LXR-induced redistribution of ABCG1 toplasma membrane in macrophages enhances cholesterol mass efflux to HDL. Kennedy, M. A. et al. Sci. 1, 121131 (2005). NiemannPick C1 like 1 gene expression is down-regulated by LXR activators in the intestine. 309, 864872 (2003). Patterson, M. C. et al. 13, e1006257 (2017). Localization of human acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) inmacrophages and in various tissues. 25, 12621274 (2011). Proc. A family of two ubiquitously expressed, membrane-associated proteins, namely, flotillin 1 and flotillin 2. eLife 6, e28766 (2017). In the meantime, to ensure continued support, we are displaying the site without styles Henderson, R., OKane, M., McGilligan, V. & Watterson, S. The genetics and screening of familial hypercholesterolaemia. Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. Table of Content Types of Bromination Bromination via a Free Radical Mechanism Bromination via an Addition Reaction Genet. Human NPC1L1 expression is positively regulated by PPAR. Lee, J. N., Song, B., DeBose-Boyd, R. A. Natl Acad. Brown, M. S. & Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline NiemannPick type C1 disease. Chem. The COMMD family regulates plasma LDL levels and attenuates atherosclerosis through stabilizing the CCC complex in endosomal LDLR trafficking. J. Biol. & Song, B. L. Intracellular cholesterol transport by sterol transfer proteins at membrane contact sites. Toxicol. Flotillins play an essential role in NiemannPick C1-like 1-mediated cholesterol uptake. Proteins with glycosylphosphatidylinositol (GPI) attached at the C-termini. Cell Metab. Thekey factors governing these pathways and the major mechanisms by which they respond tovarying sterol levels are described. Chem. 29, 17181722 (2009). Rep. 8, 6170 (2018). Natl Acad. The membrane vesicles coated by coatomer II (COP II), which is a type of vesicle coat protein that facilitates the formation of transport vesicles from the endoplasmic reticulum (ER). This study shows that hepatic ABCG5 and ABCG8 mediates cholesterol excretion into bile and that intestinal ABCG5 and ABCG8 contributes to cholesterol efflux via the non-hepatobiliary route. 275, 2824028245 (2000). J. Biol. Vaughan, A. M. & Oram, J. F. ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J. Biomed. 59, 21812187 (2018). Hepatic ABCG5 and ABCG8 overexpression increases hepatobiliary sterol transport but does not alter aortic atherosclerosis in transgenic mice. Res. 285, 1972019726 (2010). A diterpene alcohol containing 20 carbons that is synthesized in the mevalonate pathway. Acta 1761, 655666 (2006). Circ. This work identifies that squalene monooxygenase is another rate-limiting enzyme besides HMGCR in cholesterol synthesis and is subjected to cholesterol-induced degradation.

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